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Tranexamic Acid prevents plasminogen being converter to plasmin?
CRASH 2 was an RCT of TXA versus placebo in trauma patients with haemoglobin levels less than 100 g/L?
CRASH 3 looked at administration of TXA to patients with head injuries?
CRASH 3 had a positive primary outcome which showed a statitically significant difference in those patients treated with TXA?
CRASH 3 showed that TXA was more effective when given to those with a GCS of 3 and those with fixed and dilated pupils?
CRASH 3 showed that you needed to treat 6 patients with a GCS of 12 or less, a positive scan for TBI when excluding those with a GCS of 3 and with fixed and dilated pupils, in order to save a life?